The cholinergic system is pivotal in cognitive processes, sleep regulation, and inflammatory responses, particularly in critically ill patients. Delirium, a common complication in intensive care units (ICUs), is often linked to disturbances in the cholinergic system, with serum cholinesterase activities as potential biomarkers. Results published by our research group suggest that environmental factors, such as lighting, can influence circadian melatonin rhythms and potentially mitigate delirium. The following data analysis explores how modifications in ICU design, specifically incorporating dynamic light therapy, impact the oscillation of serum acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities in critically ill patients, which play crucial roles in the cholinergic system and have been linked to cognitive function and delirium in critically ill patients.
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Circadian Medicine in the Intensive Care Unit /
Patient care in the Intensive Care Unit (ICU) inevitably takes place around the clock. As a result, the contrast between day and night, which is so pervasive and prominent outside the hospital, is virtually absent in the ICU. Moreover, organ support and supportive care are typically administered with little regard to the time of day. Despite such care activities being critical for patients, these conditions provide weak and conflicting timing cues to the circadian clock, the endogenous biological timekeeper that serves to optimally synchronize 24-hour rhythms in behavior and physiology.
Read MoreModifications in ICU Design Affect Delirium & Circadian Melatonin /
We are thrilled to share that the first comprehensive research paper with data from the VITALITY study has been published in Critical Care Medicine. In this prospective observational cohort pilot study, we compared the outcome of 74 adult critically ill patients on mechanical ventilation with an expected ICU length of stay of at least 48 hours, treated in modified or standard rooms.
Read MoreLighting Therapy for ICU Patients /
A fundamental aspect of human physiology is its cyclical nature over a 24-h period, a feature conserved across most life on earth. Evidence is emerging that ICU delirium, a syndrome independently associated with increased mortality and long-term morbidity from critical illness, and affecting up to 80% of critically ill patients, is a clinical manifestation of circadian dysrhythmia. There is increasing research activity investigating the impact of lighting on human health.
Watch the clip to learn more about it - now available with subtitles in English :)
The full 45-minute report is available here for the next 12 months.